五灵子 2007-1-9 21:50
模拟题6
[font=Times New Roman]B[/font]型题：[font=Times New Roman] [/font]
[font=Times New Roman]101-104[/font]
[font=Times New Roman]A.[/font]易与受体蛋白质的羧基结合，又可形成氢键，表现出多种生物活性[font=Times New Roman] [/font]
[font=Times New Roman]B.[/font]能与生物大分子形成氢键，增强与受体间的结合力[font=Times New Roman] [/font]
[font=Times New Roman]C.[/font]增加分配系数，降低解离度[font=Times New Roman] [/font]
[font=Times New Roman]D.[/font]影响电荷分布和脂溶性[font=Times New Roman] [/font]
[font=Times New Roman]E.[/font]增加水溶性，增加与受体结合力[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]101[/font]题[font=Times New Roman] [/font]药物分子中引入氨基
[font=Times New Roman][/font]第[font=Times New Roman]102[/font]题[font=Times New Roman] [/font]药物分子中引入羟基[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]103[/font]题[font=Times New Roman] [/font]药物分子中引入酰胺基[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]104[/font]题[font=Times New Roman] [/font]药物分子中引入卤素[font=Times New Roman] [/font]
[font=Times New Roman][/font]
[font=Times New Roman]105-108[/font]
[font=Times New Roman]A.[/font]在体内代谢成亚砜[font=Times New Roman] [/font]
[font=Times New Roman]B.[/font]代谢后产生环氧化物，与[font=Times New Roman]DNA[/font]作用生成共价键化合物[font=Times New Roman] [/font]
[font=Times New Roman]C.[/font]在体内代谢时，绝大部分迅速水解成对氨基苯甲酸和二乙氨基乙醇[font=Times New Roman] [/font]
[font=Times New Roman]D.[/font]在体内有[font=Times New Roman]10%[/font]的药物经[font=Times New Roman]O-[/font]脱甲基后生成吗啡[font=Times New Roman] [/font]
[font=Times New Roman]E.[/font]进入血脑屏障后产生的脱乙基化代谢产物[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]105[/font]题[font=Times New Roman] [/font]局麻药普鲁卡因在体内很快失活的原因是
[font=Times New Roman][/font]第[font=Times New Roman]106[/font]题[font=Times New Roman] [/font]长期和大量服用镇咳药可待因会产生成瘾性是[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]107[/font]题[font=Times New Roman] [/font]黄曲霉[font=Times New Roman]B1[/font]的致癌机理是[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]108[/font]题[font=Times New Roman] [/font]利多卡因中枢副作用的原因是[font=Times New Roman] [/font]
[font=Times New Roman][/font]
[font=Times New Roman]109-111[/font]
[font=Times New Roman]A.[/font]螺内酯[font=Times New Roman] B.[/font]地尔硫（卓）[font=Times New Roman] C.[/font]胺碘酮[font=Times New Roman] D.[/font]洛伐他汀[font=Times New Roman] E.[/font]氯贝丁酯[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]109[/font]题[font=Times New Roman] [/font]在体内可迅速被酯酶分解为活性代谢物—酸的是[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]110[/font]题[font=Times New Roman] [/font]体内主要代谢途径为[font=Times New Roman]N-[/font]脱乙基的药是[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]111[/font]题[font=Times New Roman] [/font]体内代谢主要途径为脱乙酰基，[font=Times New Roman]N-[/font]脱甲基和[font=Times New Roman]O-[/font]脱甲基的是[font=Times New Roman] [/font]
[font=Times New Roman][/font]
[font=Times New Roman]112-113[/font]
[font=Times New Roman]A.[/font]艾滋病[font=Times New Roman] B.[/font]全身性带状疱疹[font=Times New Roman] C.[/font]艾滋病前期症状[font=Times New Roman] D.[/font]肺结核[font=Times New Roman] E.[/font]肝炎[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]112[/font]题[font=Times New Roman] [/font]利巴韦林临床用于治疗
[font=Times New Roman][/font]第[font=Times New Roman]113[/font]题[font=Times New Roman] [/font]阿昔洛韦临床用于治疗[font=Times New Roman] [/font]
[font=Times New Roman][/font]
[font=Times New Roman]114-116[/font]
[font=Times New Roman]A.[/font]头孢派酮[font=Times New Roman] B.[/font]头孢噻吩钠[font=Times New Roman] C.[/font]头孢克洛[font=Times New Roman] D.[/font]头孢噻肟钠[font=Times New Roman] E.[/font]头孢羟氨苄[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]114[/font]题[font=Times New Roman] 3[/font]位是乙酰氧甲基，[font=Times New Roman]7[/font]位侧链上含有[font=Times New Roman]2-[/font]氨基[font=Times New Roman]4-[/font]噻唑基的头孢菌素是
[font=Times New Roman][/font]第[font=Times New Roman]115[/font]题[font=Times New Roman] 3[/font]位上有氯取代，[font=Times New Roman]7[/font]位上有[font=Times New Roman]2-[/font]氨基苯乙酰氨基的头孢菌素是[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]116[/font]题[font=Times New Roman] 3[/font]位为乙酰氧甲基，[font=Times New Roman]7[/font]位上有[font=Times New Roman]2-[/font]噻吩乙酰氨基的头孢菌素是[font=Times New Roman] [/font]
[font=Times New Roman][/font]
[font=Times New Roman]117-119[/font]
[font=Times New Roman]A.[/font]甲氨喋呤[font=Times New Roman] B.[/font]巯嘌呤[font=Times New Roman] C.[/font]卡莫氟[font=Times New Roman] D.[/font]阿糖胞苷[font=Times New Roman] E.[/font]卡莫司汀[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]117[/font]题[font=Times New Roman] [/font]直接作用于[font=Times New Roman]DNA[/font]，用于治疗脑瘤的药物是[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]118[/font]题[font=Times New Roman] [/font]具有二氢叶酸还原酶抑制作用的药物是[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]119[/font]题[font=Times New Roman] [/font]具有抑制[font=Times New Roman]DNA[/font]多聚酶及少量掺入[font=Times New Roman]DNA[/font]作用的药物为[font=Times New Roman] [/font]
[font=Times New Roman][/font]
[font=Times New Roman]120-122[/font]
[font=Times New Roman]A.N-[/font]甲基化反应[font=Times New Roman] [/font]
[font=Times New Roman]B.17-[/font]位羟基氧化为酮基[font=Times New Roman] [/font]
[font=Times New Roman]C.3-[/font]酮还原为羟基后经硫酸酯化或葡萄糖醛酸酯化而排泄[font=Times New Roman] [/font]
[font=Times New Roman]D.[/font]芳环羟基化[font=Times New Roman] [/font]
[font=Times New Roman]E.[/font]氧化脱卤[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]120[/font]题[font=Times New Roman] [/font]醋酸氢化可的松的体内主要代谢途径为[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]121[/font]题[font=Times New Roman] [/font]米非司酮的体内主要代谢途径为[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]122[/font]题[font=Times New Roman] [/font]雌二醇的体内主要代谢途径为[font=Times New Roman] [/font]
[font=Times New Roman][/font]
[font=Times New Roman]123-125[/font]
[font=Times New Roman]A.[/font]维生素[font=Times New Roman]B6 B.[/font]维生素[font=Times New Roman]C C.[/font]维生素[font=Times New Roman]A1 D.[/font]维生素[font=Times New Roman]B2 E.[/font]维生素[font=Times New Roman]D3 [/font]
[font=Times New Roman][/font]第[font=Times New Roman]123[/font]题[font=Times New Roman] [/font]水溶液呈右旋光性，且显酸性的是[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]124[/font]题[font=Times New Roman] [/font]具有多烯结构，侧链上有四个双键，对紫外光不稳定的是[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]125[/font]题[font=Times New Roman] [/font]与[font=Times New Roman]FeCl3[/font]作用呈红色，在制备注射液时，不能用含铁盐的砂芯过滤的是[font=Times New Roman] [/font]
[font=Times New Roman][/font]
[font=Times New Roman]126-128[/font]
[font=Times New Roman]A.[/font]成环修饰[font=Times New Roman] B.[/font]成酰胺[font=Times New Roman] C.[/font]开环修饰[font=Times New Roman] D.[/font]成酯修饰[font=Times New Roman] E.[/font]成酯、盐或酰胺[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]126[/font]题[font=Times New Roman] [/font]针对药物的羧基的化学修饰通常为[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]127[/font]题[font=Times New Roman] [/font]针对药物的氨基的化学修饰通常为[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]128[/font]题[font=Times New Roman] [/font]针对药物的羟基的化学修饰通常为[font=Times New Roman] [/font]
[font=Times New Roman][/font]
[font=Times New Roman]129-132[/font]
[font=Times New Roman]A.[/font]半衰期[font=Times New Roman] B.[/font]分子折射率[font=Times New Roman] C.[/font]脂水分配系数[font=Times New Roman] D.[/font]解离常数[font=Times New Roman] E.[/font]半数致死量[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]129[/font]题[font=Times New Roman] [/font]生物活性参数是[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]130[/font]题[font=Times New Roman] [/font]电性参数是[font=Times New Roman] [/font]
[font=Times New Roman][/font]第[font=Times New Roman]131[/font]题[font=Times New Roman] [/font]疏水性参数是[font=Times New Roman] [/font]
第132题 立体参数是